Epigenetic regulation in gastric cancer; Viral and bacterial infections in gastric carcinogenesis; Mechanism of chronic inflammation-driven gastric carcinogenesis

Univ. of Southern California,PhD, Biochemistry and Molecular Biology, 1999-2006
Univ. of Calgary, Dept. of Biochemistry and Molecular Biology, 1998-1999 PhD student
Shanghai Inst. of Biochemistry, M. Sc, Biochemistry and Molecular Biolgy, 1993-1997
Wuhan University, B. Sc, Biochemistry , 1989-1993

Assistant Professor, Shanghai Jiao Tong University, 2009- present
Postdoc Fellow, Univ. of California at Los Angeles,Geffen School of Medicine, Hillbillom Islet Research Center 2007-2009

A main aspect of the lab research focuses on the tumor suppression mechanism of epigenetic regulator TET1 in gastric cancer. It appears that TET1-mediated 5hmc production can induce p53 activation, which suppresses EZH2, leading to tumor suppression. Another area of the lab research is about the relation of chronic inflammation and gastric cancer. Chronic inflammation can be caused by viral, bacterial infections or by sterile inflammation. The lab is particularly interested in the complicate immune cell behaviors associated with chronic inflammation during gastric carcinogenesis. We found that neutrophils are heavily present in gastric cancer tissues and negatively correlated to E-cadherin expression. Neutrophils likely play imporant regulatory roles in gastric cancer formation.

Nanochemistry and Molecular Biolgoy

1, Hualin Fu, Yue Ma, Meng Yang, Chunlei Zhang, Hai Huang, Ying Xia, Lungen Lu, Weilin Jin & Daxiang Cui. Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation. Sci Rep. 2016 Jul 14;6:29762.
2, Hua-Lin Fu, Yue Ma, Lun-Gen Lu, Peng Hou, Bao-Jie Li, Wei-Lin Jin, and Da-Xiang Cui. TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer. Journal of Biomedical Nanotechnology 2014，10(7): 1217-1230
3，Hualin Fu, Ishii Mamoru, Gu Ying, Robert Maxson. Conditional alleles of Msx1 and Msx2 . Genesis， 2007 Aug; 45(8): 477-814
4，Hualin Fu. What is the material base of acupuncture? The nerves! Medical Hypothesis， 2000 Mar; 54(3) 358-9
5, Josie X. Zhou, Sangeeta Dhawan, Hualin Fu, Emily Snyder, Rita Bottino, Sharmistha Kundu, Seung K. Kim, and Anil Bhushan*. Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J Clin Invest., 2013, 123(11): 4849–4858
6, Yanyang Tu, Xingchun Gao, Gang Li, Hualin Fu, Daxiang Cui, Hui Liu, Weilin Jin, and Yongsheng Zhang. MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1. Cancer Res., 2013, 73(19):6046-55